Methods: A randomized, controlled trial was con- ducted to prevent depressive episodes in at-risk off- spring (aged 13-18 years) of adults treated for depres- sion in a health maintenance organization (HMO). Potential adult cases were found by reviewing the HMO pharmacy records for dispensation of antidepres- sant medication and the mental health appointment system. Medical charts were reviewed for a depression diagnosis. Recruitment letters signed by treating physicians were mailed to adults. Eligible offspring had subdiagnostic depressive symptoms insufficient to meet full DSM-III-R criteria for affective disorder and/or a past mood disorder. These youth were ran- domized to usual HMO care (n=49)

Background: Adolescent offspring of depressed par- ents are at high risk for development of depression. Cog- nitive restructuring therapy holds promise for prevent-
ing progression to depressive episodes.

Objective: To evaluate the effect of fluoxetine hydrochlo- ride vs placebo onmajor depressive disorder, substance use disorder (SUD), and conduct disorder (CD) in adolescents receiving cognitive behavioral therapy (CBT) for SUD.
Design: Randomized controlled trial.

Objective: To evaluate the effect of fluoxetine hydrochlo- ride vs placebo onmajor depressive disorder, substance use disorder (SUD), and conduct disorder (CD) in adolescents receiving cognitive behavioral therapy (CBT) for SUD.
Design: Randomized controlled trial.
Setting: A single-site study conducted betweenMay 2001
and August 2004.